. Erythromycin, azithromycin and clarithromycin are known as macrolides because their structure contain ………………….
Succinctly summarize the mechanism of action of the macrolides.
Mention the microbial source of erythromycin and the natural habitat of this source.
Erythromycin is both a narrow spectrum and bacteriostatic antibiotic. Briefly explain.
Chloramphenicol was once a highly prescribed antibiotic and a number of deaths from anemia occurred before its use was curtailed. Now it is seldom used in human medicine except in life-threatening situations. Explain this fact.
Describe briefly the mechanism of action of chloramphenicol.
Mention the microbial source of chloramphenicol and one bacterial infection it can be used to treat.
Enumerate three (3) mechanism of microbial resistance to chloramphenicol.
What is mutation?
Describe in details four (4) mechanism of drug resistance.
What is the full meaning of the acronyms XDRTB and MDRTB?
X-ray the significance of antibiotic sensitivity testing in clinical medicine.
Tetracyclines are broad-spectrum and bactericidal antibiotics. Briefly explain.
Enumerate five (5) diseases/infections that tetracyclines can be used to treat.
What is the mechanism of action of the tetracyclines?
Why are tetracyclines contraindicated during pregnancy?
Outline five (5) members of the Mycobacterium tuberculosis complex (MTC).
Why are mycobacteria regarded as acid-fast bacteria (AFB)?
Enumerate five (5) anti-TB drugs of your choice.
Succinctly describe the clinical significance of DOT in TB therapy.