Virology

MORPHOLOGY OF VIRUSES

Written by MicroDok

A virion is composed mainly of three parts viz: the nucleic acid genome (DNA or RNA); the capsid or nucleocapsid; and the envelopes which surround the capsid or protein coat. The nucleic acid genome of a virus or virion can assume any of the following genetic composition:

  • Double-stranded DNA (dsDNA)
  • Single-stranded DNA (ssDNA)
  • Double-stranded RNA (dsRNA)
  • Single-stranded RNA (ssRNA)

Viruses assume different shapes and sizes. Morphologically, viruses have four main types of structures based on their capsid structure viz: icosahedral or cubic viruses, complex viruses and helical viruses. Some viruses however have envelops and are thus known as enveloped viruses. Icosahedral viruses or cubic viruses have a symmetry that is in a closed shell; and typical example of viruses in this morphological group is the adenoviruses (Figure 1). The icosahedral symmetry is exhibited by both DNA and RNA viruses. Some viruses have a spherical symmetry (Figure 2).  The helical symmetry is most common amongst viruses in the orthomyxoviridae family and the tobacco mosaic viruses that infect plants also have a helical structure. Helical structure is formed when the protein subunits of the virion are bound in a periodic pattern to the viral nucleic acid in such a way that it is wound into a helix (Figure 3). Viruses with a spherical shape usually assume a circular or globular structure. Influenzavirus in the Orthomyxoviridae family is an example of a virus with a spherical structure.

Icosahedral symmetry is an example of cubic symmetry assumed by most viruses. And the icosahedral symmetry is exhibited by both DNA-containing viruses and RNA-containing viruses. Typical examples of viruses with the icosahedral symmetry are those in the viral families: Caliciviridae, Astroviridae, Picornaviridae, Birnaviridae, Reoviridae, Parvoviridae, Polyomaviridae, Papillomaviridae, Adenoviridae, Hepadnaviridae and Bornaviridae. Viral spikes are external polypeptide projections found on the surface of viruses and which aid in the attachment or adsorption of viruses to the surface of their host cell(s). They form part of the polypeptide molecules that make up a virion. Other viral polypeptides aside viral spikes include: membrane proteins, haemagglutinins, membranes and nucleocapsid. Helical symmetry is another typical viral shape assumed by most viruses especially the RNA-containing viruses. Most of the animal viruses with helical symmetry that infect animals including humans have RNA-containing genomes. The tobacco mosaic virus (TMV) – which infects plants, is a typical example of virus with a helical symmetry.

Figure 1: Illustration of viral icosahedral symmetry.

Viruses that do not show either the icosahedral or helical symmetry form a complex structure; and such viruses have an architectural plan that resembles a brick-shaped configuration with ridges on the outside and lateral bodies and core on the inside (Figure 3). Poxvirus and bacteriophages are examples of viruses that form complex symmetry. Complex viruses as shown in Figure 4 have a tail or tube-like structure through which its nucleic acid genome is inserted into the host cell they infect. The viral nucleic acid genome (DNA or RNA) contains the genetic information of the virion and it is also responsible for directing the infectiousness of the virus. The capsid or protein coat (which can be icosahedral, helical or complex) provides a protective function for the virion in that it protects the nucleic acid genome from enzymatic action. It is antigenic in nature, and the capsid also acts as specific binding sites that mediate binding or attachment of the virus to their host cell. The envelope consists mainly of lipid bilayers and glycoproteins which facilitate the entry of the virion into the infected host cell.

Figure 2: Illustration of spherical symmetry.

Figure 3: Illustration viral helical symmetry.

Figure 4: Structure of T4 bacteriophage, a complex virus. The different components of the phage are: baseplate, tail fibers, sheath, core, collar and head.

SELECTED REFERENCES

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Alba R, Bosch A and Chillon M (2005). Gutless adenovirus: last-generation adenovirus for gene therapy. Gene Ther, Suppl 12:S18-S27.

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MicroDok

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