Agents of bioterrorism are usually found in the hands of terrorists, scientists, and most of all some rogue nations. In the hands of the extremists, biological and chemical agents used for terrorism are unsafe and can be used with or without provocation to cause threat, economic panic, sickness, and death in a target human population. But these agents are controlled under international laws in the hands of the research organizations and governments or countries that have them in their weaponry. However, some countries (as experienced in recent times) can use these chemical and biological agents as offensives against their enemies even in the slightest provocation. While biological weapons (made form microbes including bacteria, viruses and fungi) may not be stockpiled by governments of nations due to the ease in producing them, a handful of developed countries have stockpiles of chemical weapons (e.g. sarin gas and mustard gas) in their military hardware’s. Also, mischievous private organizations with good financial backings can also start and stockpile biological and chemical weapons, and these can be accessible to terrorists who use them to cause terror and death in human populations.
Thus, the Chemical Weapons Convention (CWC) to which many nations of the world (especially those with stockpiles of chemical weapons) are signatories to, and the United Nations Disarmament Act helps to restrict nations in possession of chemical and biological weapons from using them, and most importantly adhere strictly to the prohibition of their usage and constantly give themselves to international scrutiny in order to ensure that they are complying to laid down rules regarding these agents. Table 1 summarizes the distinguishing features of biological agents (i.e. microorganisms) which are usually used for bioterrorism attack by terrorists.
Virtually all biological agents pose one health risk or the other, but possessing them do not make them a hypothetical threat until they have been weaponized and distributed in actual fact to their target human or animal population. Though a plethora of microbes and their metabolic products (e.g. toxins) may meet the criteria of a weaponized biological agent and be regarded as one, the U.S. Center for Disease Control and Prevention (CDC) has deemed it fit to catalog recognized microbes of terror based on their potency and threat. According to the CDC, biological agents of terrorism are placed in three (3) priority categories based on initial public health efforts and the apparent threat of these agents. These three categories of biological agents are highlighted in the next section.
Table 1: Summary of characteristics of selected bioterrorism agents
Data from: Klietmann W.F and Ruoff K.L (2001). Bioterrorism: implications for the clinical microbiologist. Clin. Microbiol. Rev, 14(2)364-381.
Riedel S (2004). Biological warfare and bioterrorism: a historical overview. BUMC Proceedings, 17:400-406.
Poupard J. A and Miller L. A (1992). History of biological warfare: catapults to capsomeres. Ann. N.Y. Acad. Sci. 666:9–20.
Klietmann W.F and Ruoff K.L (2001). Bioterrorism: implications for the clinical microbiologist. Clin. Microbiol. Rev, 14(2)364-381.
Health and Safety Executive (HSE) (2002). Control of Substances Hazardous to Health: Approved Codes of Practice, 4th edition. HSE Books. Sudbury.
Guillemin J (2006). Scientists and the history of biological weapons. European Molecular Biology Organization (EMBO) Reports, Vol 7, Special Issue: S45-S49.
Biosafety in Microbiological and Biomedical Laboratories. 5th edition. U.S Department of Health and Human Services. Public Health Service. Center for Disease Control and Prevention. National Institute of Health. HHS Publication No. (CDC) 21-1112.2009.
Porta M (2008). A dictionary of epidemiology. 5th edition. New York: Oxford University Press.
Nelson K.E and Williams C (2013). Infectious Disease Epidemiology: Theory and Practice. Third edition. Jones and Bartleh Learning.
Murray P.R., Rosenthal K.S., Kobayashi G.S., Pfaller M. A. (2002). Medical Microbiology. 4th edition. Mosby Publishers, Chile.
Murray P.R, Baron E.J, Jorgensen J.H., Pfaller M.A and Yolken R.H (2003). Manual of Clinical Microbiology. 8th edition. Volume 1. American Society of Microbiology (ASM) Press, Washington, D.C, U.S.A.
Murray P.R, Baron E.J, Jorgensen J.H., Pfaller M.A and Yolken R.H (2003). Manual of Clinical Microbiology. 8th edition. Volume 2. American Society of Microbiology (ASM) Press, Washington, D.C, U.S.A.
Mandell G.L, Bennett J.E, Dolin R, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 5th ed. Philadelphia: Churchill Livingstone, 2002.
Madigan M.T., Martinko J.M., Dunlap P.V and Clark D.P (2009). Brock Biology of Microorganisms, 12th edition. Pearson Benjamin Cummings Inc, USA.