The major differences between viral and non-vectors used for gene therapy applications are as shown in Table 1.
Table 1: DIFFERENCE BETWEEN VIRAL AND NON-VIRAL VECTORS
|S/No.||Viral vectors||Non-viral vectors|
|1.||Highly efficient in transferring desired genes.||Less or fairly efficient in transferring desired genes.|
|2.||Viral vectors pose some health risk to the recipient
|Non-viral vectors are usually safer to use, and they do not pose any health risk to the recipient patient.|
|3.||Viral vectors are used for in vivo gene therapy to
deliver desired genes through the process of
|Non-viral vectors are used for ex vivo gene therapy to deliver desired genes through the process known as transfection.|
|4.||Viruses (e.g. adeno-associated viruses and adenoviruses)are used as vectors.||Non-viral vectors such as gene gun or microinjection and calcium phosphate precipitate e.t.c. are used as vehicles to convey the gene of interest into the body of the host.|
Fig. 1. Synoptic illustration of how genes are delivered during gene therapy technique
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